Implementation of polygenic risk score guided breast cancer precision prevention
The project has been supported by the Norway Grants Green ICT programme.

Project AnteNOR
Project implementation period: 01.07.2021-30.04.2024
Grant amount: 761 360,20 €
Total budget: 1 523 025 €
Antegenes has registered and CE-certified a breast cancer genetic risk test AnteBC that is based on polygenic risk scores technology. AnteBC allows to differentiate women’s genetic predisposition to breast cancer and to make more specific recommendations for the prevention and early detection of breast cancer.
Project’s goal
Project result
About us
Project main progress
July – December 2021
- AnteNOR project kick-off
- Green ICT project was mentioned in Delfi Ärileht article
- Mapped and interviewed Norwegian key stakeholders in the field of breast cancer and breast cancer mammography screening
- Applied and received the ethical commitee approval for genetic analysis study
- Analysis of Norwegian genetic data started
- Antegenes became a member of Oslo Cancer Cluster
- Presentation about Antegenes and AnteNOR project at Oslo Cancer Cluster virtual annual meeting on 15th of December
January – June 2022
- Started cooperation with Oecona AS
- Participated in EXPO 2020 Dubai for international scientific cooperations
- Green ICT project was mentioned in e-Estonia blog article.
- Development of the cost-benefit simulation study for Norwegian medical setting
- AnteNOR seminar was organized in Oslo by Oslo Cancer Cluster and Antegenes
- AnteNOR project clinical pilot study protocol created and ready
- Application for conducting the AnteNOR clinical pilot is submitted to Regional Ethical Commitee
July – December 2022
- Approval of the Ethics Committee to implement study in Oslo University Hospital and Vestre Viken Hospital was obtained.
- Clinical study was registered in the ClinialTrials.gov database.
- Clinical study logistics pathways were developed, study assistant was involved by Vestre Viken Hospital.
- Retrospective performance assessment of Antegenes PRS in Norwegian data has been conducted. Initial results have been compiled and presented as a poster at the Nordic Society of Human Genetics and Precision Medicine 2022 conference “Precision Medicine Research And Implementation: Rebooting In The Nordics Post-Covid” (3-4 November 2022, Copenhagen, Denmark) (Akdeniz et al. “Implementation of polygenic risk score guided breast cancer prediction in Norwegian data”).
- Oecona developed the cost-utility preliminary model for Norwegian medical setting. Collaboration with health economists of Sweden was launched.
- Norway specific health technology assessment and implementation options specific to Norwegian healthcare were developed.
- The article “Preventing breast cancer in Norway” was written and published on Oslo Cancer Cluster website.
January – June 2023
- A cost-benefit study assessing a AnteBC based breast cancer screening routine in comparison with alternatives is completed.
- Information from external and internal sources for health technology assessment was collected and developed.
- The clinical pilot was launched in February in Oslo University Hospital and Vestre Viken Hospital.
- AnteBC polygenic risk model is recalibrated for use in Norwegian population. The manuscript is under submission.
- Genetics guided breast cancer screening program policy document draft has been developed and introduced to partners and external experts in Norway and the UK.
- Three articles were written and published on Oslo Cancer Cluster website:
1. February 23 about the clinical study launch.