Skin Melanoma Personalized Screening Program

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Incidences of skin melanoma are rising in many European countries and all over the world.

Early discovery of the disease means that the chance of survival is high, but when detected late, the prognosis is poor.

There are currently no centrally organized population-based screening programs for melanoma in Europe. The majority of melanomas are initially self-discovered. For those at high melanoma risk (due to significant UV exposure, family history, hereditary risk, etc.), the recommendation is a routine full-body visual examination of the skin.

The heritability of melanoma is among the highest among cancers, with many genetic variants of small effects contributing to the disease. It is possible to summarize these risks using polygenic risk scores. Studies have indicated that among individuals with low conventional risk factors, around 9–21% belong to a high polygenic risk group. Therefore, genomic testing can identify people who are susceptible to melanoma despite their lack of a traditional phenotypic risk profile.

We have developed a program for personalized prevention of skin melanoma. For that, we have designed and implemented the test based on the polygenic risk score, which estimates the genetic risk for melanoma – AnteMEL. AnteMEL is one of the foundations for the prevention and early detection of cutaneous melanoma. The purpose of the AnteMEL test is to reduce the risk of premature mortality due to melanoma through primary and secondary prevention measures. According to the risk level, the personalized prevention program also offers recommendations for health behavior and indications for medical geneticist consultation and testing of single high-risk melanoma susceptibility genes.

The program can be used in ordering the AnteMEL test. The program is suitable for men and women in age 18-70.